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Please note: These electronic articles are posted for individual, non-commercial use to ensure timely dissemination of scholarly work. They are intended for teaching and training purposes only. Articles may not be reposted or disseminated without permission by the copyright holder. Copyright holders retain all rights as indicated within each article.

 

* Denotes that the first author is a current or former student/trainee or member of my lab

2019

Published

Keywords: psychiatry, mental health, online therapy, social therapy, first-episode psychosis
HORYZONS trial: Protocol for a randomized controlled trial of a moderated online social therapy to maintain treatment effects from first-episode psychosis services

Alvarez,-Jimenez, M., Bendall, S., Koval, S., Cagliarini, D., Valentine, L., D’Alfonso, S., Miles, C., Russon, P., Penn, D. L., Phillips, J., Lederman, R., Wadley, G., Killackey, E., Echarri-Santesteban, O., Mihalopoulos, C., Herrman, H., Blanch-Gonzalez, C., Gilbertson, T., Lai, S., Chambers, R., Daglas-Georgiou, R., Latorre, C., Cotton, S. M., McGorry, P. D., & Gleeson, J. F. (2019). HORYZONS trial: Protocol for a randomized controlled trial of a moderated online social therapy to maintain treatment effects from first-episode psychosis services. British Medical Journal: Open, 9, Article number=e024104. doi:10.1136/bmjopen-2018-024104

The objective of this trial was to determine whether extending the treatment period of a specialized FEP service through an 18-month, step-down, novel online social media-based intervention (HORYZONS) produces better outcomes compared with 2 years of specialist FEP treatment followed by treatment as usual (TAU), using a randomized controlled single-blind design. An additional aim of this trial is to determine the cost-effectiveness of HORYZONS....read more
Published

Keywords: first episode psychosis, early intervention, schizophrenia, observer-rated therapeutic alliance
Client predictors of the therapeutic alliance in individual resiliency training for first episode psychosis

*Browne, J., Bass, E., Mueser, K.T., Meyer-Kalos, P, Gottlieb, J. D., Estroff, S. E., & Penn, D. L. (2019). Client predictors of the therapeutic alliance in individual resiliency training for first episode psychosis. Schizophrenia Research, 204, 375-380. doi:10.1016/j.schres.2018.07.035

The exploratory aim was to examine associations between demographic variables (age, race, and gender) and the therapeutic alliance (TA). The present study included a subsample of participants (n = 134) who received Individual Resiliency Training (IRT) as part of the NAVIGATE treatment in the Recovery After An Initial Schizophrenia Episode Early Treatment Program study....read more
Published

Keywords: recovery, schizophrenia, early psychosis, treatment engagement
The relationship between the therapeutic alliance and client variables in individual treatment for schizophrenia spectrum disorders and early psychosis: Narrative review

*Browne, J., Kurtz, M., Berry, K., Nagendra, A., & Penn, D. L. (2019). The relationship between the therapeutic alliance and client variables in individual treatment for schizophrenia spectrum disorders and early psychosis: Narrative review. Clinical Psychology Review, 71, 51-62. doi:10.1016/j.cpr.2019.05.002

This review provides a comprehensive discussion of the relationship between the alliance and client variables across various provider types and individual treatments. This review summarizes existing research on (a) client correlates/predictors of the therapeutic alliance and on (b) the relationship between the alliance and client treatment outcomes in individual treatment for schizophrenia spectrum disorders and early psychosis....read more
Published

Keywords: recovery, first episode psychosis, early intervention, working relationship, therapist effects
The therapeutic alliance in individual resiliency training for first episode psychosis: Relationship with treatment outcomes and therapy participation

*Browne, J., Mueser, K. T., Meyer-Kalos, P., Gottlieb, J. D., Estroff, S. E., & Penn, D. L. (2019). The therapeutic alliance in individual resiliency training for first episode psychosis: Relationship with treatment outcomes and therapy participation. Journal of Consulting and Clinical Psychology, 87, 734-744. doi:10.1037/ccp0000418

The present study examined the alliance at Session 3, 4, or 5 and its relationship to 2-year treatment outcomes and therapy participation in a sample of 144 FEP clients who received specialized FEP treatment at U.S. clinics. Furthermore, we examined between-therapist and within-therapist (client) effects of the alliance on outcomes....read more
Published

Keywords: schizophrenia spectrum disorders, paranoia, interpersonal functioning, network analysis
Paranoia and interpersonal functioning across the continuum from healthy to pathological – Network analysis

Hajduk M., Klein, H. S., Harvey, P. D., Penn, D. L., & Pinkham, A. E. (2019). Paranoia and interpersonal functioning across the continuum from healthy to pathological – Network analysis. British Journal of Clinical Psychology, 58, 19-34. doi:10.1111/bjc.12199

This study analysed the relationship between paranoia and interpersonal functioning across the paranoia continuum using network analysis. Levels of paranoid ideation and interpersonal functioning were measured in a non-clinical sample (N = 853) and in patients with schizophrenia spectrum disorders (N = 226)....read more
Published

Keywords: oxytocin, social behavior, psychosis, schizophrenia, schizoaffective disorder
Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial

*Halverson, T., Jarskog, L. F., Pedersen, C., & Penn, D. L. (2019). Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial. Schizophrenia Research, 204, 178-182. doi:10.1016/j.schres.2018.09.013

We tested the hypothesis that twice-daily intranasal oxytocin administered for 12-weeks would improve tertiary and exploratory outcomes of self-reported social symptoms, empathy and introspective accuracy from the Jarskog et al. (2017) randomized controlled trial. Sixty-eight stable outpatients with schizophrenia or schizoaffective disorder were randomized to receive oxytocin (24 IU twice daily) or placebo....read more
Published

Keywords: schizophrenia, psychosis, functional outcome, community functioning, quality of life, social cognition, neurocognition
Pathways to functional outcomes in schizophrenia spectrum disorders: Meta-analysis of social cognitive and neurocognitive predictors

*Halverson, T. F., Pobee, M. O., Merritt, C., Sheeran, P., Fett, A.K., & Penn, D. L. (2019). Pathways to functional outcomes in schizophrenia spectrum disorders: Meta-analysis of social cognitive and neurocognitive predictors. Neuroscience and Biobehavioral Reviews, 105, 212-219. doi:10.1016/j.neubiorev.2019.07.020

The current meta-analysis explored relationships between functional outcomes in schizophrenia spectrum disorders and different domains of neurocognition and social cognition. Of 1361 articles identified, 166 met all inclusion criteria (12,868 participants; 518 correlations)....read more
Published

Keywords: social functioning, social cognition, social competence, symptom severity, schizophrenia
Predictors of social functioning in patients with higher and lower levels of reduced emotional experience: Social cognition, social competence, and symptom severity

Harvey, P. D., Deckler, E., Jarskog, L. F., Penn, D. L., & Pinkham, A. (2019). Predictors of social functioning in patients with higher and lower levels of reduced emotional experience: Social cognition, social competence, and symptom severity. Schizophrenia Research, 206, 271-276. doi:10.1016/j.schres.2018.11.005

Participants with schizophrenia (n = 312) were tested using five different measures of social cognition. Performance-based assessments and clinical ratings of reduced emotion experience were used to assess social competence. High contact informants rated interpersonal functioning and social acceptability of behavior, while unaware of other patient data....read more
Published

Keywords: autism symptoms, depression, active social avoidance, schizophrenia, everyday functioning
Autism symptoms, depression, and active social avoidance in schizophrenia: Association with self-reports and informant assessments of everyday functioning

Harvey, P. D, Deckler, E., Jones, M. T., Jarskog, L. F., Penn, D. L., & Pinkham, A. E. (2019). Autism symptoms, depression, and active social avoidance in schizophrenia: Association with self-reports and informant assessments of everyday functioning. Journal of Psychiatric Research, 115, 36-42. doi:10.1016/j.jpsychires.2019.05.010

Participants were 177 patients with schizophrenia who self-reported their everyday functioning and social cognitive ability as well as their depression. Correlations between self-reported everyday functioning and social cognitive ability, ratings of everyday functioning and social cognitive ability, and the discrepancies between those ratings were examined for correlations with depression, autistic features and social avoidance....read more
Published

Keywords: schizophrenia, self-assessment, introspective accuracy, depression
Depression and reduced emotional experience in schizophrenia: Correlations with self-reported and informant-rated everyday social functioning

Harvey, P. D., Deckler, E., Jones, M. T., Jarskog, L. F., Penn, D. L., & Pinkham, A. E. (2019). Depression and reduced emotional experience in schizophrenia: Correlations with self-reported and informant-rated everyday social functioning. Journal of Experimental Psychopathology, 10, Article number = 20438080719829313. doi:10.1177/2043808719829313

We examined depression and reduced emotional experience and self-reports and informant ratings of social functioning and social cognitive abilities in 135 patients with schizophrenia. Discrepancies between sources were used to index the accuracy and bias in self-assessment....read more
Published

Keywords: loneliness, social anxiety disorder, positive psychology intervention, digital intervention, youth mental health
A pilot digital intervention targeting loneliness in youth mental health

Lim, M. H., Rodebaugh T. L., Eres, R., Long, K. M., Penn, D. L., & Gleeson, J. F. (2019). A pilot digital intervention targeting loneliness in youth mental health. Frontiers in Psychiatry, 10, Article number = 604. doi:10.3389/fpsyt.2019.00604

We tested the acceptability, feasibility, and safety of the program in lonely young people with or without a mental health diagnosis of social anxiety disorder. Nine participants with a diagnosis of social anxiety disorder (Mage = 21.00; SD = 1.41) and 11 participants with no mental health conditions (Mage = 20.36; SD = 2.16) completed the +Connect digital intervention....read more
Published

Keywords: autism spectrum disorder, adults, reliability, social social cognition, validity
Psychometric evaluation of social cognitive measures for adults with autism

Morrison, K. E., Pinkham, A. E., Kelsven, S., Ludwig, K., Penn, D. L., & Sasson, N. J. (2019). Psychometric evaluation of social cognitive measures for adults with autism. Autism Research, 12, 766-778. doi:10.1002/aur.2084

The current study provides psychometric evaluation of 11 frequently used measures encompassing different subdomains of social cognition. Adults with autism (N = 103) and typically developing controls (N = 95) completed 11 commonly used social cognitive tasks spanning the domains of emotion processing, social perception, and mentalizing/theory of mind....read more
Published

Keywords: implementation, fidelity, training, coordinated specialty care
Implementation and fidelity assessment of the NAVIGATE treatment program for first episode psychosis in a multi-site study

Mueser, K. T., Meyer, P. S., Glynn, G. M., Lynde, D. W., Robinson, D. E., Gingerich, S., Penn, D. L., Cather, C., Gottlieb, J. D., Marcy, P., Wiseman, J., Potretzke, S., Brunette, M. F., Schooler, N. R., Addington, J., Rosenheck, R. A., Estroff, S. E., & Kane, J. M. (2019). Implementation and fidelity assessment of the NAVIGATE treatment program for first episode psychosis in a multi-site study. Schizophrenia Research, 204, 271-281. doi:10.1016/j.schres.2018.08.015

This article describes the approach to training and implementing the NAVIGATE program at the 17 sites (including 134 practitioners) randomized to provide it, and to evaluating the fidelity of service delivery to the NAVIGATE model. Fidelity was evaluated to five different components of the program, all of which were standardized in manuals in advance of implementation....read more

2018

Published

Keywords: functional recovery, at risk mental state, internet, online
Enhancing social functioning in young people at Ultra High Risk (UHR) for psychosis: A pilot study of a novel strengths and mindfulness-based online social therapy

Alvarez-Jimenez, M., Gleeson, M. F., Bendall, S., Yung, A. R., Ryan, R. M., Eleftheriadis, D., D’Alfonso, S., Rice, S., Miles, C., Russon, P. Lederman, R., Chambers, R., Gonzalez-Blanch, C., Lim, M., Killackey, E., McGorry, P. D., Nelson, B., & Penn, D. L. (2018). Enhancing social functioning in young people at Ultra High Risk (UHR) for psychosis: A pilot study of a novel strengths and mindfulness-based online social therapy. Schizophrenia Research, 202, 369-377. doi:10.1016/j.schres.2018.07.022

An international, multidisciplinary team developed a new intervention (MOMENTUM) to improve social functioning in UHR young people. MOMENTUM blends two novel approaches to social recovery: strengths and mindfulness-based intervention embedded within a social media environment, and application of the self-determination theory of motivation. The acceptability and safety of MOMENTUM were tested through a 2-month pilot study with 14 UHR participants....read more
Published

Keywords: adherence, competence, fidelity, psychosis, psychosocial treatment
Factor structure of therapist fidelity to individual resiliency training in the Recovery After an Initial Schizophrenia Episode Early Treatment Program

*Browne, J., Edwards, A. N., Penn, D. L., Meyer-Kalos, P. S., Gottlieb, J. D., Julian, P., Ludwig, K., Mueser, K. T., & Kane, J. M. (2018). Factor structure of therapist fidelity to individual resiliency training in the Recovery After an Initial Schizophrenia Episode Early Treatment Program. Early Intervention in Psychiatry, 12, 1052-1063. doi:10.1111/eip.12409

A comprehensive psychosocial/psychiatric program for this population, NAVIGATE, includes an individual therapy component, individual resiliency training (IRT). The data found can provide insight into the elements of the therapeutic process in this intervention. The RAISE-ETP study included 34 clinical sites randomized to provide NAVIGATE (n = 17) or CC (n = 17). The entire study included 404 subjects who met criteria for a schizophrenia spectrum disorder....read more
Published

Keywords: positive psychology, strengths-based therapy, recovery, early intervention
Character strengths of individuals with first episode psychosis in Individual Resiliency Training

*Browne, J., Estroff, S. E., Ludwig, K., Merritt, C., Meyer-Kalos, P., Mueser, K. T., Gottlieb, J. D., & Penn, D. L. (2018). Character strengths of individuals with first episode psychosis in Individual Resiliency Training. Schizophrenia Research, 195, 448-454. doi:10.1016/j.schres.2017.09.036

The present study offers an examination of character strengths among 105 FEP clients in specialized early intervention treatment. The present study included two primary aims: 1) to conduct a descriptive analysis of character strengths of FEP individuals and 2) to examine exploratory associations between character strengths and changes in symptomatic and recovery variables over six months....read more
Published

Keywords: schizophrenia, first episode, substance use disorder, alcohol, cannabis, drug
Demographic and clinical correlates of substance use disorders in first episode psychosis

Brunette, M. F., Mueser, K. T., Babbin, S., Meyer-Kalos, P., Rosenheck, R., Correll, C., Cather, C., Robinson, D. G., Schooler, N. R., Penn, D. L., Addington, J., Estroff, S. E., Gottlieb, J., Glynn, S. M., Marcy, P., Robinson, J., & Kane, J. M. (2018). Demographic and clinical correlates of substance use disorders in first episode psychosis. Schizophrenia Research, 194, 4-12. doi:10.1016/j.schres.2017.06.039

Research staff assessed 404 first episode patients at 34 community mental health centers across the United States with the Structured Clinical Interview for DSM-IV for diagnoses of psychotic and substance use disorders. Logistic regression was used to evaluate the relationships between participant characteristics and lifetime substance use disorders, followed with generalized linear mixed-effects regression models to identify unique predictors of lifetime substance use disorders....read more
Published

Keywords: schizophrenia, social cognition, functioning, psychometrics
The bias toward intentionality in schizophrenia: Automaticity, context, and relationships to symptoms and functioning

*Buck, B., Hester, N. R., Pinkham, A., Harvey, P. D., Jarskog, L. F., & Penn, D. L. (2018). The bias toward intentionality in schizophrenia: Automaticity, context, and relationships to symptoms and functioning. Journal of Abnormal Psychology, 127, 503-512. doi:10.1037/abn0000360

Research in social psychology suggests that nonclinical individuals present with an automatic bias to see intentionality and that this bias is regulated by the operation of controlled processes. The present study examined whether this general intentionality bias distinguishes individuals with schizophrenia (n 213) from nonpatient controls (n=151). Indeed, individuals with schizophrenia were more likely to attribute intentional motives to others’ actions relative to controls....read more
Published

Keywords: early-phase psychosis, early intervention services (EIS), treatment as usual (TAU), schizophrenia spectrum disorder
Comparison of early intervention services vs treatment as usual for early-phase psychosis: A systematic review, meta-analysis, and meta-regression

Correll, C. U., Galling, B., Pawar, A., Krivko, A., Bonetto, C., Ruggeri, M., Craig, T., Mordentoft, M., Srihari, V. H., Guloksuz, S., Hui, C. L. M., Chen, E., Y. H., Valencia, M., Juarez, F., Robinson, D. G., Schooler, N. R., Brunette, M. F., Mueser, K. T., Rosenheck, R. A., Marcy P., Addington, J., Estroff, S. E., Robinson, J., Penn, D. L., Goldstein, A., Severe, J., & Kanem, J. M. (2018). Comparison of early intervention services vs treatment as usual for early-phase psychosis: A systematic review, meta-analysis, and meta-regression. Journal of the American Medical Association: Psychiatry, 75, 555-565. doi:10.1001/jamapsychiatry.2018.0623

The objective of this study was to compare early intervention services (EIS) with treatment as usual (TAU) for early-phase psychosis. s In this meta-analysis of 10 randomized clinical trials (n = 2176 patients), early intervention services were associated with better outcomes than treatment as usual at the end of treatment regarding all meta-analyzable outcomes....read more

Web of Science highly cited paper as of May 2021
Published

Keywords: early-phase psychosis, early intervention services (EIS), treatment as usual (TAU), schizophrenia spectrum disorder
Social Cognition and Neurocognition in Schizophrenia and Healthy Controls: Intercorrelations of Performance and Effects of Manipulations Aimed at Increasing Task Difficulty

Deckler, E., Hodgins, G., Pinkham, A., Penn, D. L., & Harvey, P. D. (2018). Social cognition and neurocognition in schizophrenia and healthy controls: Intercorrelations of performance and effects of manipulations aimed at increasing task difficulty. Frontiers in Psychiatry, 9, Article 356. doi:10.3389/fpsyt.2018.00356.

Social cognition (SC) and neurocognition appear to predict different aspects of functional outcome in people with schizophrenia. However, the correlations between performance on these domains have not been tested extensively and compared cross-diagnostically with healthy controls. Further, some social cognitive measures appeared to have potential ceiling effects, particularly for healthy people, in previous research, so increasing their difficulty is of interest...read more
Published

Keywords: social cognitive impairments, schizophrenia, Social Cognition Psychometric Evaluation (SCOPE) project
Social cognitive impairments in individuals with schizophrenia vary in severity

Hajduk, M., Harvey, P. D., Penn, D. L., & Pinkham, A. E. (2018). Social cognitive impairments in individuals with schizophrenia vary in severity. Journal of Psychiatric Research, 104, 65-71. doi:10.1016/j.jpsychires.2018.06.017

The present study evaluated the heterogeneity of social cognitive impairment. A secondary aim was to identify a subset of measures to quickly identify those individuals who are most in need of remediation. Two independent samples of people with schizophrenia (n = 176; n = 178) and their respective healthy control groups (n = 104; n = 154) were selected from two phases of the Social Cognition Psychometric Evaluation (SCOPE) project, which assessed multiple domains of social cognition....read more
Published

Keywords: clinical high risk, ultra high risk, neurocognition, psychosis, functioning, early intervention, negative symptoms
Latent profile analysis and conversion to psychosis: Characterizing subgroups to enhance risk prediction

*Healey, K., Penn, D. L., Perkins, D. O., Woods, S., Keefe, R., & Addington, J. (2018). Latent profile analysis and conversion to psychosis: Characterizing subgroups to enhance risk prediction. Schizophrenia Bulletin, 104, 286-296. doi:10.1093/schbul/sbx080

The aim is to enhance model validity by adding diagnostically relevant clinical and neurocognitive indicators and to further characterize latent subgroups with covariates. The sample consisted of 171 CHR participants (98 males, 73 females) with a mean age of 19.8 (SD = 4.5) and 100 HSC participants (56 males, 44 females) with a mean age of 19.4 (SD = 3.9) years....read more
Published

Keywords: social skill, social functioning, schizophrenia, social cognition
Evaluating social skill in individuals with schizophrenia with the brief impression questionnaire (BIQ)

*Lanser, K., Browne, J., Pinkham, A., Harvey, P., Jarskog, L., & Penn, D. L. (2018). Evaluating social skill in individuals with schizophrenia with the brief impression questionnaire (BIQ). Psychiatry Research, 269, 38-44. doi:10.1016/j.psychres.2018.08.047

The purpose of this study was to investigate the psychometric properties of the Brief Impression Questionnaire (BIQ), a novel measure designed to utilize immediate impression formation in the assessment of social skill in schizophrenia. Twenty-two research assistants at three sites rated participants using the BIQ (154 control participants and 218 individuals with schizophrenia)....read more
Published

Keywords: loneliness, perceived social isolation, psychosis, systematic review
Loneliness in psychosis: A systematic review

Lim, M., Gleeson, M., Alvarez-Jimenez, M., & Penn, D. L. (2018). Loneliness in psychosis: A systematic review. Social Psychiatry and Psychiatric Epidemiology, 53, 221-238. doi:10.1007/s00127-018-1482-5

The aim of the review is to understand the relationships between loneliness and related psychological and social factors in individuals with psychosis. A total of ten studies examining loneliness in people diagnosed with a psychotic disorder were examined. Heterogeneity in the assessment of loneliness was found, and there were contradictory findings on the relationship between loneliness and psychotic symptomatology....read more

Web of Science highly cited paper as of May 2021
Published

Keywords: mental disorders, schizophrenia, eHealth, well-being, internet, technology
Using digital technology in the treatment of schizophrenia

Lim, M., & Penn, D. L. (2018). Using digital technology in the treatment of schizophrenia. Schizophrenia Bulletin, 44, 937-938. doi:10.1093/schbul/sby081

A survey of psychiatric patients (N = 320) recruited from different services across the United States found that the patients’ interest in using digital technologies such as smartphones to monitor mental health was as high as 70.6%. Of the 320 psychiatric patients surveyed, 80% had access to the internet, and 62.5% owned a smartphone....read more
Published

Keywords: early intervention, first episode psychosis, individual therapy, mindfulness, positive psychology
Enhancing stress-reactivity and well-being in early schizophrenia: A pilot study of individual coping awareness therapy (ICAT) (Letter to the Editor)

*Meyer-Kalos, P. S., Ludwig, K. A., Gaylord, S., Perkins, D. O., Grewen, K., Palsson, O. S., Burchinal, M., & Penn, D. L. (2018). Enhancing stress-reactivity and well-being in early schizophrenia: A pilot study of individual coping awareness therapy (ICAT) (Letter to the Editor). Schizophrenia Research, 201, 413-414. doi:10.1016/j.schres.2018.04.039

I-CAT includes two core elements: 1) in vivo practice of mindfulness and positive psychology strategies and 2) development of an individualized plan that is incorporated into a person's daily routine. I-CAT involves up to 26 one-hour, individual sessions....read more
Published

Keywords: RAISE-ETP study, race, first-episode psychosis, schizophrenia, demographic, psychosocial measures, clinical measures, neurocognitive measures
Demographic, psychosocial, clinical, and neurocognitive baseline characteristics of Black Americans in the RAISE-ETP study

*Nagendra, A., Schooler, N. R., Kane, J. M., Robinson, D. G., Mueser, K. T., Estroff, S. E., Addington, J., Marcy, P., & Penn, D. L. (2018). Demographic, psychosocial, clinical, and neurocognitive baseline characteristics of Black Americans in the RAISE-ETP study. Schizophrenia Research, 193, 64-68. doi:10.1016/j.schres.2017.06.038

This study compared baseline characteristics of Black Americans and Caucasians with first-episode psychosis in the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP). Black American (N = 152) and Caucasian (N = 218) participants were compared on demographic, psychosocial, clinical, and neurocognitive measures. Results indicated several notable racial differences in baseline characteristics....read more
Published

Keywords: severe mental illness, psychometrics, racial minority, schizophrenia
Social cognition and African American men: The roles of perceived discrimination and experimenter race on task performance

*Nagendra, A., Twery, B. L., Neblett, E. W., Mustafic, H., Jones, T. S., Gatewood, D., & Penn, D. L. (2018). Social cognition and African American men: The roles of perceived discrimination and experimenter race on task performance. Psychiatry Research, 259, 21-26. doi:10.1016/j.psychres.2017.09.074

As an initial step, we investigated whether race, independent of mental illness status, affects performance on the SCOPE battery. Thus, we examined the effects of perceived discrimination and experimenter race on the performance of 51 non-clinical African American men on the SCOPE battery. Results revealed that these factors impacted social cognitive task performance....read more
Published

Keywords: schizophrenia, measurement, reliability, validity, emotion processing, social perception, mental state attribution, attributional style
Social Cognition Psychometric Evaluation (SCOPE): Results of the final validation study

*Pinkham, A. E., Harvey, P. D., & Penn, D. L. (2018). Social Cognition Psychometric Evaluation (SCOPE): Results of the final validation study. Schizophrenia Bulletin, 44, 737-748. doi:10.1093/schbul/sbx117

The Social Cognition Psychometric Evaluation (SCOPE) study addresses this need by systematically evaluating the psychometric properties of promising measures. In this final phase of SCOPE, eight new or modified tasks were evaluated. Stable outpatients with schizophrenia (n = 218) and healthy controls (n = 154) completed the battery at baseline and 2–4 weeks later across three sites....read more

Web of Science highly cited paper as of May 2021
Published

Keywords: social cognition, insight, self-assessment, disability, social functioning
Self-assessment of social cognitive ability in schizophrenia: Association with social cognitive test performance, informant assessments of social cognitive ability, and everyday outcomes

Silberstein, J., Pinkham, A. E., Penn, D. L., & Harvey, P. D. (2018). Self-assessment of social cognitive ability in schizophrenia: Association with social cognitive test performance, informant assessments of social cognitive ability, and everyday outcomes. Schizophrenia Research, 199, 75-82. doi:10.1016/j.schres.2018.04.015

People with schizophrenia (n = 135) performed 8 different tests of social cognition. They were asked to rate their social cognitive abilities on the Observable Social Cognition Rating Scale (OSCARs). Social competence was measured with a performance-based assessment and clinical ratings of negative symptoms were also performed....read more

Schizophrenia Research most cited article as of May 2021
Published

Keywords: negative symptoms, cognitive impairments, schizophrenia, functional deficits
Which levels of cognitive impairments and negative symptoms are related to functional deficits in schizophrenia?

Strassnig, M., Harvey, P., Pinkham, A. E., Penn, D. L., Twamley, E., Patterson, T. L., & Bowie, C. (2018). Which levels of cognitive impairments and negative symptoms are related to functional deficits in schizophrenia? Journal of Psychiatric Research, 104, 124-129. doi:10.1016/j.jpsychires.2018.06.018

People diagnosed with chronic schizophrenia (n = 821) were assessed with the MCCB and PANSS, and rated by high contact informants with SLOF. Negative symptoms of reduced emotional experience were specifically targeted for analysis because of their previously identified relationships with social outcomes....read more

2017

Published

Keywords: autonomy, first-episode psychosis, RAISE Early
Treatment Program, quality of life
Perceived autonomy support in the NIMH RAISE early treatment program

*Browne, J., Penn, D. L., Bauer, D. J., Meyer-Kalos, P. S., Mueser, K. T., Robinson, D. G., Addington, J., Schooler, N., Glynn, S. M., Gingerich, S., Marcy, P., & Kane, J. M. (2017). Perceived autonomy support in the NIMH RAISE early treatment program. Psychiatric Services, 68, 916-922. doi:10.1176/appi.ps.201600480

This study examined perceived autonomy support among the 404 individuals with first-episode psychosis who participated in the RAISE ETP trial (NAVIGATE, N=223; community care, N=181). Three-level conditional linear growth modeling was used given the nested data structure....read more
Published

Keywords: first episode psychosis, psychological well-being, coordinated specialty care
Psychological well-being and mental health recovery in the NIMH RAISE early treatment program

*Browne, J., Penn, D. L., Meyer-Kalos, P. S., Mueser, K. T., Estroff, S. E., Schooler, N., Robinson, D. G., Addington, J., Marcy, P., & Kane, J. M. (2017). Psychological well-being and mental health recovery in the NIMH RAISE early treatment program. Schizophrenia Research, 185, 167-172. doi:10.1016/j.schres.2016.11.032

The primary aims of the present analysis were: 1) to examine the impact of treatment on PWB and mental health recovery trajectories, 2) to examine the impact of duration of untreated psychosis (DUP) on these outcomes, and 3) to examine the relationships among these outcomes and quality of life....read more
Published

Keywords: paranoia, psychosis, mind perception, social cognition
Differential patterns in mind perception in subclinical paranoia: relationships to self-reported empathy

*Buck, B. E., Hester, N. R., Penn, D. L., & Gray, K. (2017). Differential patterns in mind perception in subclinical paranoia: relationships to self-reported empathy. Cognitive Neuropsychiatry, 22, 137-144. doi:10.1080/13546805.2017.1287692

We examined links between mind perception and paranoia in a large (n = 890) subclinical sample. Participants completed measures of paranoia, schizotypy, mind perception, and dispositional empathy. These assessments were examined for their relationships to one another, as well as the possibility that mind perception partially mediates the relationship between paranoia and empathy....read more
Published

Keywords: schizophrenia, social cognition, functioning, psychometrics
Improving measurement of attributional style in schizophrenia: A psychometric evaluation of the Ambiguous Intentions Hostility Questionnaire (AIHQ)

*Buck, B. E., Iwanski, C., Healey, K. M., Green, M. F., Horan, W. P., Kern, R. S., Lee, J., Marder, S. R., Reise, S. P., & Penn, D. L. (2017). Improving measurement of attributional style in schizophrenia: A psychometric evaluation of the Ambiguous Intentions Hostility Questionnaire (AIHQ). Journal of Psychiatric Research, 89, 48-54. doi:10.1016/j.jpsychires.2017.01.004

The present study evaluated the psychometric properties of the AIHQ while concurrently testing changes aiming to improve the scale, in particular expansion of the number of self-report items and removal of the rater-scored items. One hundred sixty individuals diagnosed with schizophrenia and 58 healthy controls completed the full AIHQ along with measures of symptoms, functioning, and verbal intelligence....read more
Published

Keywords: schizophrenia, social cognition, effort, task difficulty
Self-assessment of social cognitive ability in individuals with schizophrenia: Appraising task difficulty and allocation of effort

Cornacchio, D., Pinkham, A., Penn, D. L., & Harvey, P. D. (2017). Self-assessment of social cognitive ability in individuals with schizophrenia: Appraising task difficulty and allocation of effort. Schizophrenia Research, 179, 85-90. doi:10.1016/j.schres.2016.09.033

This study compares patients with schizophrenia to healthy individuals on their social cognitive performance, their assessment of that performance, and the convergence between performance and indicators of effort in solving tasks. Patients with schizophrenia (n = 57) and healthy controls (HC; n = 47) completed the Bell-Lysaker Emotion Recognition Test (BLERT), a psychometrically sound assessment of emotion recognition....read more
Published

Keywords: cognition, social cognition, schizophrenia, treatment, cognitive remediation
Understanding Social Situations (USS): A proof-of-concept social cognitive intervention targeting theory of mind and attributional bias in individuals with psychosis

Fiszdon, J.M., Roberts, D. L., Penn, D. L., Choi, K-H., Tek, C., Choi, J. & Bell, M. D. (2017). Understanding Social Situations (USS): A proof-of-concept social cognitive intervention targeting theory of mind and attributional bias in individuals with psychosis. Psychiatric Rehabilitation Journal, 40, 12-20. doi:10.1037/prj0000190

Thirty-eight individuals with schizophrenia spectrum disorders completed the same baseline assessment of cognitive and social–cognitive functioning twice over a 1-month period to minimize later practice effects, then received 7–10 sessions of USS training, and then completed the same assessment again at post treatment....read more
Published

Keywords: schizophrenia, social cognition, empathy, psychometrics, role-play
Are social skill and empathy separable constructs? A psychometric evaluation of a new role-play assessment of empathy for individuals with schizophrenia

*Gagen, E. C., Gibson, C. M., Elliott, T., Smedley, K., Jarskog, J. F., Pedersen, C. A., & Penn, D. L. (2017). Are social skill and empathy separable constructs? A psychometric evaluation of a new role-play assessment of empathy for individuals with schizophrenia. Journal of Experimental Psychopathology, 8, 175-191. doi:10.5127/jep.050715

The present study evaluated the psychometric properties of a role-play measure of empathy, the Performance of Empathic Expression Rating Scale (PEERS), in a sample of 60 individuals with schizophrenia and 51 healthy controls. The role-play ratings assess a person's ability to interact empathically with a confederate in an emotionally charged situation. The PEERS demonstrated acceptable internal consistency and inter-rater reliability....read more
Published

Keywords: oxytocin, social cognition, psychosis, schizophrenia, schizoaffective disorder, negative symptoms
A 12-week randomized controlled trial of twice-daily intranasal oxytocin for social cognitive deficits in people with schizophrenia

Jarskog, L. F., Pedersen, C. A., Johnson, J. L., Hamer, R. M., Rau, S. W., Elliott, T., & Penn, D. L. (2017). A 12-week randomized controlled trial of twice-daily intranasal oxytocin for social cognitive deficits in people with schizophrenia. Schizophrenia Research, 185, 88-95. doi:10.1016/j.schres.2017.01.008

This study tested the hypothesis that 12 weeks of intranasal oxytocin will improve social cognitive function in outpatients with schizophrenia and schizoaffective disorder. Sixty-eight eligible participants were randomized to oxytocin (24 IU twice daily) or placebo....read more
Published

Keywords: first episode psychosis, schizophrenia, social cognition, measurement, psychometric evaluation
Social cognition psychometric evaluation (SCOPE) in people with early psychosis: A preliminary study

*Ludwig, K. A., Pinkham, A. E., Harvey, P. D., Kelsven, S., & Penn, D. L. (2017). Social cognition psychometric evaluation (SCOPE) in people with early psychosis: A preliminary study. Schizophrenia Research, 190, 136-143. doi:10.1016/j.schres.2017.03.001

The current study expands upon the SCOPE study by examining the psychometric properties of the eight candidate measures administered to individuals early in the course of psychosis. Thirty-eight stable outpatients with first episode psychosis and thirty-nine healthy controls completed the battery at baseline and one-month follow-up assessments....read more
Published

Keywords: social skills, social interaction, social cognition, social behavior
Distinct profiles of social skill in adults with autism spectrum disorder and schizophrenia

Morrison, K. E., Pinkham, A. E., Penn, D. L., Kelsven, S., & Sasson, N. J. (2017). Distinct profiles of social skill in adults with autism spectrum disorder and schizophrenia. Autism Research, 10, 878-887. doi:10.1002/aur.1734

The current study provides the first direct and detailed comparison of social behavior in the two disorders by identifying profiles of social skill in adults with ASD (n = 54), SCZ (n = 54), and typically developing (TD) controls (n = 56) during a real-world social interaction. ASD and SCZ groups exhibited poorer social skill, both overall and on most discrete abilities, relative to the TD group....read more
Published

Keywords: measurement, emotion recognition, mental state attribution
The effect of age, race, and sex on social cognitive performance in individuals with schizophrenia

*Pinkham, A. E., Kelsven, S., Kouros, C., Harvey, P. D, & Penn, D. L. (2017). The effect of age, race, and sex on social cognitive performance in individuals with schizophrenia. Journal of Nervous and Mental Disease, 205, 346-352. doi:10.1097/NMD.0000000000000654

Data from 170 individuals with schizophrenia or schizoaffective disorder and 98 healthy controls were used to examine relations between these demographic factors and performance across multiple domains and measures of social cognition. Sex was not related to performance on any domain, but older age was related to poorer emotion recognition from dynamic stimuli in both patients and controls....read more

2016

Published

Keywords: schizophrenia, exercise, health, physical activity, walking
Work out by walking: A pilot exercise program for individuals with schizophrenia spectrum disorders

*Browne, J., Penn, D. L., Battaglini, C., & Ludwig, K. A. (2016). Work out by walking: A pilot exercise program for individuals with schizophrenia spectrum disorders. Journal of Nervous and Mental Disease, 240, 651-657. doi:10.1097/NMD.0000000000000556

The current pilot study developed and evaluated the impact of Work out by Walking (WOW), a multicomponent group walking intervention on the health of 16 individuals with SSDs. Results indicated improvements in indicators of physical health, activity level, social support, and mental health and a high level of program satisfaction....read more
Published

Keywords: serious mental illness, exercise, health, walking, focus groups
Focus on exercise: Client and clinician perspectives on exercise in individuals with serious mental illness

*Browne, J., Mihas, P., & Penn, D. L. (2016). Focus on exercise: Client and clinician perspectives on exercise in individuals with serious mental illness. Community Mental Health Journal, 52, 387-394. doi:10.1007/s10597-015-9896-y

Twelve clients and fourteen clinicians participated in focus groups aimed at examining exercise, barriers, incentives, and attitudes about walking groups. Results indicated that clients and clinicians identified walking as the primary form of exercise, yet barriers impeded consistent participation....read more
Published

Keywords: emotion processing, theory of mind, social cognitive skill, confirmatory factor analysis (CFA)
Social cognition in schizophrenia: Factor structure of emotion processing and theory of mind

*Browne, J., Penn, D. L., Raykov, T., Pinkham, A. E., Kelsven, S., Buck, B., & Harvey, P.D. (2016). Social cognition in schizophrenia: Factor structure of emotion processing and theory of mind. Psychiatry Research, 242, 150-156. doi:10.1016/j.psychres.2016.05.034

The aims of the present study were to: 1) examine the factor structure of social cognition in schizophrenia through the utilization of psychometrically sound measures, 2) examine the stability of the factor structure across two study visits, 3) compare the factor structure of social cognition in schizophrenia to that in healthy controls, and 4) examine the relationship between the factors and relevant outcome measures including social functioning and symptoms....read more
Published

Keywords: cognitive impairment, schizophrenia, social cognition, theory of mind
Social cognition in schizophrenia: Factor structure, clinical and functional correlates

*Buck, B. E., Healey, K. M., Gagen, E. C., Roberts, D. L., & Penn, D. L. (2016). Social cognition in schizophrenia: Factor structure, clinical and functional correlates. Journal of Mental Health, 8, 1-8. doi:10.3109/09638237.2015.1124397

A factor analysis was conducted on social cognition measures in a sample of 65 individuals with schizophrenia or schizoaffective disorder, and 50 control participants. The resulting factors were examined for their relationships to symptoms and functioning....read more
Published

Keywords: social cognitive bias, schizophrenia, Social Cognition Psychometric Evaluation (SCOPE) study
Revisiting the validity of measures of social cognitive bias in schizophrenia: Additional results from the Social Cognition Psychometric Evaluation (SCOPE) study

*Buck, B. E., Pinkham, A. E., Harvey, P. D., & Penn, D. L. (2016). Revisiting the validity of measures of social cognitive bias in schizophrenia: Additional results from the Social Cognition Psychometric Evaluation (SCOPE) study. British Journal of Clinical Psychology, 55, 441-454. doi:10.1111/bjc.12113

Two measures of social cognitive bias – the Ambiguous Intention Hostility Questionnaire (AIHQ; hostile attribution bias) and Trustworthiness Task (distrust bias) – were reviewed according to their relationships to (1) current and prospective symptom levels, (2) questionnaires of trait paranoia and hostility and informant-rated hostility, (3) interpersonal conflict, as well as (4) relationships to measures of trait paranoia, hostility, and interpersonal conflict above and beyond the influence of clinically rated symptoms....read more
Published

Keywords: first episode psychosis, early psychosis, social cognition, schizophrenia, theory of mind, emotion processing
Deficits in social cognition in first episode psychosis: A review of the literature

*Healey, K.M., Bartholomeusz, C., & Penn, D. L. (2016). Deficits in social cognition in first episode psychosis: A review of the literature. Clinical Psychology Review, 50, 441-454. doi:10.1016/j.cpr.2016.10.001

The goal of the current article is to review and synthesize the current body of work examining SC in FEP. Secondary aims are to examine the relationship between SC and symptoms, and change in SC over time in FEP. Data from 48 relevant studies (6 longitudinal) were reviewed and integrated....read more
Published

Keywords: first-episode psychosis, NAVIGATE, treatment, schizophrenia
Comprehensive versus usual community care for first episode psychosis: Two-year outcomes from the NIMH RAISE early treatment program

Kane, J. M., Robinson, D. G., Schooler, N. R., Mueser, K. T., Penn, D. L., Rosenheck, R. A., Addington, J. Brunette, M. F., Correll, C. U., Estroff, S. E., Marcy, P., Robinson, J., Meyer-Kalos, P. S., Gottlieb, J. D., Glynn, S., Lynde, D. W., Pipes, R., Kurian, B. T., Miller, A. L., Azrin, S. T., Goldstein, A. B., Severe, J. B., Lin, H., Sint, J. K., John, M., & Heinssen, R. K. (2016). Comprehensive versus usual community care for first episode psychosis: Two-year outcomes from the NIMH RAISE early treatment program. American Journal of Psychiatry, 173, 362-372. doi:10.1176/appi.ajp.2015.15050632

Thirty-four clinics in 21 states were randomly assigned to NAVIGATE or community care. Diagnosis, duration of untreated psychosis, and clinical outcomes were assessed via live, two-way video by remote, centralized raters masked to study design and treatment. Participants (mean age, 23) with schizophrenia and related disorders and #6 months of antipsychotic treatment (N=404) were enrolled and followed for >2 years....read more

Web of Science highly cited paper as of May 2021
Published

Keywords: social cognition, psychosocial treatments, affect recognition, theory-of-mind, schizophrenia
Comprehensive treatments for social cognitive deficits in schizophrenia: A critical review and effect-size analysis of controlled studies

Kurtz, M. M., Gagen, E., Rocha, N. B. F, Machado, S., & Penn, D. L. (2016). Comprehensive treatments for social cognitive deficits in schizophrenia: A critical review and effect-size analysis of controlled studies. Clinical Psychology Review, 43, 80-89. doi:10.1016/j.cpr.2015.09.003

A critical literature review and effect-size (ES) analysis was conducted to investigate the efficacy of comprehensive programs of social cognitive training in schizophrenia. Results revealed 16 controlled studies consisting of seven models of comprehensive treatment with only three of these treatment models investigated in more than one study....read more
Published

Keywords: bipolar disorder, emotion perception, smell identification, social cognition, theory of mind
Relationship between olfactory function and social cognition in euthymic bipolar patients

Lahera, G., Ruiz-Murugarren, S., Fernandez-Liria, A., Saiz-Ruiz, J., Buck, B., & Penn, D. L. (2016). Relationship between olfactory function and social cognition in euthymic bipolar patients. CNS Spectrums, 21, 53-59. doi:10.1017/S1092852913000382

The present study seeks to explore the association between olfactory ability and social cognition, especially facial emotion perception, in euthymic bipolar patients. Thirty-nine euthymic outpatients meeting DSM-IV-TR criteria for bipolar disorder and 40 healthy volunteers matched on socio-demographic criteria were recruited....read more
Published

Keywords: schizophrenia, attachment, psychosis, social cognition, psychometrics
Assessment of attachment in psychosis: A psychometric cause for concern

*Olbert, C. O., Penn, D. L., Reise, S. P., Horan, W. P., Kern, R. S., Lee, J., & Green, M. F. (2016). Assessment of attachment in psychosis: A psychometric cause for concern. Psychiatry Research, 246, 77-83. doi:10.1016/j.psychres.2016.09.020

The current study examined the latent structure of the self-report Psychosis Attachment Measure (PAM) and its relationship to lower-level perceptual and higher-order inferential social cognitive processes. The PAM was administered to 138 psychiatrically stable outpatients with schizophrenia alongside a battery of symptom, social cognitive, and functional measures....read more
Published

Keywords: social cognition, attributions, functional outcome, paranoia
Paranoid individuals with schizophrenia show greater social cognitive bias and worse social functioning than non-paranoid individuals with schizophrenia

*Pinkham, A. E., Harvey, P. D., & Penn, D. L. (2016). Paranoid individuals with schizophrenia show greater social cognitive bias and worse social functioning than non-paranoid individuals with schizophrenia. Schizophrenia Research: Cognition, 3, 33–38. doi:10.1016/j.scog.2015.11.002

Data from 147 individuals with schizophrenia were used to examine whether actively paranoid and non-paranoid individuals with schizophrenia differ in social cognition and functional outcomes. On measures assessing social cognitive bias, paranoid individuals endorsed more hostile and blaming attributions and identified more faces as untrustworthy; however, paranoid and non-paranoid individuals did not differ on emotion recognition and theory of mind tasks assessing social cognitive ability....read more

Schizophrenia Research: Cognition, among the most downloaded articles as of May 2021
Published

Keywords: schizophrenia, measurement, reliability, validity, emotion processing, social perception, mental state attribution
Social cognition psychometric evaluation (SCOPE): Results of the initial psychometric study

*Pinkham, A. E., Penn, D. L., Green, M. F., & Harvey, P. D. (2016). Social cognition psychometric evaluation (SCOPE): Results of the initial psychometric study. Schizophrenia Bulletin, 42, 494-504. doi:10.1093/schbul/sbv056

As part of the Social Cognition Psychometric Evaluation (SCOPE) study, the psychometric properties of 8 tasks were assessed. One hundred and seventy-nine stable outpatients with schizophrenia and 104 healthy controls completed the battery at baseline and a 2–4-week retest period at 2 sites....read more

Web of Science highly cited paper as of May 2021
Published

Keywords: schizophrenia, cost-effectiveness, quality adjusted life years
Cost effectiveness of comprehensive, integrated care for first episode psychosis in the NIMH RAISE early treatment program

Rosenheck, R., Leslie, D., Sint, K., Lin, H., Robinson, D. G., Schooler, N. R., Mueser, K. T., Penn, D. L., Addington, J., Brunette, M. F., Correll, C. U., Estroff, S. E., Marcy, P., Robinson, J., Rupp, A., Schoenbaum, M., & Kane, J. M. (2016). Cost effectiveness of comprehensive, integrated care for first episode psychosis in the NIMH RAISE early treatment program. Schizophrenia Bulletin, 42, 896-906. doi:10.1093/schbul/sbv224

This study compares the cost-effectiveness of Navigate (NAV), a comprehensive, multidisciplinary, team-based treatment approach for first episode psychosis (FEP) and usual Community Care (CC) in a cluster randomization trial. Patients at 34 community treatment clinics were randomly assigned to either NAV (N = 223) or CC (N = 181) for 2 years....read more
Published

Keywords: implicit vs. explicit processing, threat perception, emotion recognition, affect misattribution
Intact implicit processing of facial threat cues in schizophrenia

Shasteen, J. R. Pinkham, A. E., Kelsven, S., Ludwig, K., Payne, B. K., & Penn, D. L. (2016). Intact implicit processing of facial threat cues in schizophrenia. Schizophrenia Research, 170, 150–155. doi:10.1016/j.schres.2015.11.029

Data from 126 participants with schizophrenia and 84 healthy controls revealed that although performing more poorly on an assessment of explicit emotion recognition, patients showed normative implicit threat processing for both non-emotional and emotional facial cues....read more

2015

Published

Keywords: duration of untreated psychosis (DUP), first-episode psychosis, schizophrenia, psychotic symptoms
Duration of untreated psychosis in community treatment settings in the United States

Addington, J., Heinssen, R. K., Robinson, D. G. Schooler, N. R., Marcy, P., Brunette, M. F., Correll, C. U., Estroff, S., Mueser, K. T., Penn, D. L., Robinson, J. A., Rosenheck, R. A., Azrin, S. T., Goldstein, A. B., Severe, J., & Kane, J. M. (2015). Duration of untreated psychosis in community treatment settings in the United States. Psychiatric Services, 66, 753-756. doi:10.1176/appi.ps.201400124

This study is the first to examine duration of untreated psychosis (DUP) among persons receiving care in community mental health centers in the United States. Participants were 404 individuals (ages 15–40) who presented for treatment for first-episode psychosis at 34 nonacademic clinics in 21 states. DUP and individual- and site-level variables were measured....read more
Published

Keywords: schizophrenia, language, narrative, cognition, social functioning
Lexical characteristics of emotional narratives in schizophrenia: Relationships with symptoms, functioning, and social cognition

*Buck, B. E, & Penn, D. L. (2015). Lexical characteristics of emotional narratives in schizophrenia: Relationships with symptoms, functioning, and social cognition. Journal of Nervous and Mental Disease, 203, 702-708. doi:10.1097/NMD.0000000000000354

Brief narratives of individuals with schizophrenia (n = 42) and non-clinical controls (n = 48) were compared according to their lexical characteristics, and these were examined for relationships to social cognition and real-world functioning....read more
Published

Keywords: social cognition, schizophrenia, schizophrenia spectrum illness, measurement, functional outcome
Observable Social Cognition - A Rating Scale: an interview-based assessment for schizophrenia

*Healey, K. M., Combs, D. R., Gibson, C. M., Keefe, R. S. E., & Penn, D. L. (2015). Observable Social Cognition - A Rating Scale: an interview-based assessment for schizophrenia. Cognitive Neuropsychiatry, 20, 198-221. doi:10.1080/13546805.2014.999915

Individuals with schizophrenia consistently show impairments in social cognition (SC). The present study used the Observable Social Cognition: A Rating Scale (OSCARS) in 62 outpatients and 50 non-psychiatric controls (NPCs) to assess performance in domains of SC (e.g. emotion perception, theory of mind)....read more
Published

Keywords: schizophrenia, empathy, social functioning, social cognition, QCAE
Structure and correlates of self-reported empathy in schizophrenia

Horan, W. P, Reise, S. P., Kern, R. S., Lee, J., Penn, D. L., & Green, M. F. (2015). Structure and correlates of self-reported empathy in schizophrenia. Journal of Psychiatric Research, 66, 60-66. doi:10.1016/j.jpsychires.2015.04.016

The current study evaluated the structure and correlates of the recently-developed Questionnaire of Cognitive and Affective Empathy (QCAE) in schizophrenia. Stable outpatients with schizophrenia (n = 145) and healthy individuals (n = 45) completed the QCAE, alternative measures of empathy, and assessments of clinical symptoms, neurocognition, and functional outcome....read more
Published

Keywords: schizophrenia, negative symptoms, social competence, social cognition, social functioning
Social cognition, social competence, negative symptoms, and social outcomes: Inter-relationships in people with schizophrenia

Kalin, M., Kaplan, S., Gould, F., Pinkham, A., Penn, D. L., & Harvey, P.D. (2015). Social cognition, social competence, negative symptoms, and social outcomes: Inter-relationships in people with schizophrenia. Journal of Psychiatric Research, 68, 254-260. doi:10.1016/j.jpsychires.2015.07.008

In this study, we examined the correlations between everyday social outcomes, a performance based measure of social competence, and performance on 8 different social cognition tests in 179 patients with schizophrenia. Social cognition, social competence, and motivation-related negative symptoms accounted for 32% of the variance in real-world social outcomes....read more
Published

Keywords: RAISE, treatment model, experimental intervention, quality of life, schizophrenia
The RAISE early Treatment program for first-episode psychosis: Background, rationale, and study design

Kane, J. M., Schooler, N. R., Marcy, P., Correll, C. U., Brunette, M. F., Mueser, K. T. Rosenheck, R. A., Addington, J., Estroff, S. E., Penn, D. L., & Robinson, D. G. (2015). The RAISE early Treatment program for first-episode psychosis: Background, rationale, and study design. Journal of Clinical Psychiatry, 76, 240-246. doi:10.4088/JCP.14m09289

We developed a treatment model and training program based on extensive literature review and expert consultation. Our primary aim is to compare the experimental intervention to “usual care” on quality of life. Secondary aims include comparisons on remission, recovery, and cost-effectiveness....read more
Published

Keywords: early intervention, Individual Resiliency Training (IRT), first-episode psychosis, schizophrenia, RAISE
Individual resiliency training: An early intervention approach to enhance well-being in people with first-episode psychosis

*Meyer, P. S., Gottlieb, J. D., Penn, D. L., Mueser, K. T., & Gingerich, S. (2015). Individual resiliency training: An early intervention approach to enhance well-being in people with first-episode psychosis. Psychiatric Annals, 45, 554–560. doi:10.3928/00485713-20151103-06

This article describes Individual Resiliency Training (IRT), the individual therapy component of the Recovery After Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP). Two illustrative cases show how people can use information and skills within the IRT modules to make progress toward recovery and learn individualized skills to address common challenges....read more
Published

Keywords: NAVIGATE Program, first-episode psychosis, family education program (FEP), individual resiliency training (IRT), supported employment and education (SEE), intervention
The NAVIGATE program for first-episode psychosis: Rationale, overview, and description of psychosocial components

Mueser, K. T., Penn, D. L., Addington, J., Brunette, M. F., Gingerich, S., Glynn, S. M., Lynde, D. W., Gottlieb, J. D., Meyer-Kalos, P., Cather, C., McGurk, S. R., Saade, S., Robinson, D. G., Schooler, N. R., Rosenheck, R. A., & Kane, J. M. (2015). The NAVIGATE program for first-episode psychosis: Rationale, overview, and description of psychosocial components. Psychiatric Services, 66, 680-690. doi:10.1176/appi.ps.201400413

This article describes the background, rationale, and nature of the intervention developed by the RAISE Early Treatment Program project—known as the NAVIGATE program— with a particular focus on its psychosocial components. A cluster-randomized controlled trial comparing NAVIGATE with usual community care has recently been completed....read more
Published

Keywords: first-episode psychosis, schizophrenia, prescription patterns, early-phase treatment, RAISE-ETP study
Prescription practices in the treatment of first-episode schizophrenia spectrum disorders: Data from the national RAISE-ETP study

Robinson, D. G., Correll, C. U., Schooler, N. R., Marcy, P., Majnu, J., Addington, J., Brunette, M. F., Estroff, S. E., Mueser, K. T., Penn, D. L., Robinson, J., Rosenheck, R. A., Severe, J. Goldstein, A., Azrin, S., Heinssen, R., & Kane, J. M. (2015). Prescription practices in the treatment of first-episode schizophrenia spectrum disorders: Data from the national RAISE-ETP study. American Journal of Psychiatry, 172, 237-248. doi:10.1176/appi.ajp.2014.13101355

Prescription data at study entry were obtained from 404 participants in the Recovery After an Initial Schizophrenia Episode Project’s Early Treatment Program (RAISE-ETP), a nationwide multisite effectiveness study for patients with first-episode schizophrenia spectrum disorders. Treatment with antipsychotics did not exceed 6 months at study entry....read more
Published

Keywords: schizophrenia, cognition, negative symptoms, social functioning, functional capacity
Determinants of different aspects of everyday outcome in schizophrenia: The roles of negative symptoms, cognition, and functional capacity

Strassnig, M. T., Raykov, T., O’Gorman, C., Bowie, C. R., Sabbag, S., Durand, D., Patterson, T. L., Pinkham, A., Penn, D. L., & Harvey, P. D. (2015). Determinants of different aspects of everyday outcome in schizophrenia: The roles of negative symptoms, cognition, and functional capacity. Schizophrenia Research, 165, 76-82. doi:10.1016/j.schres.2015.03.033

We present analyses of pooled data from four separate studies (all n > 169; total n = 821) that assessed differential aspects of disability and their potential determinants. We hypothesized that negative symptoms would predict social outcomes, but not vocational functioning or everyday activities and that cognition and functional capacity would predict vocational functioning and everyday activities but not social outcomes....read more

2014

Published

Keywords: schizophrenia, exercise, health, physical activity, walking
Metacognitive functioning in individuals at clinical high risk for psychosis

Barbato, M., Penn, D. L., Perkins, D. O., Woods, S. W., Liu, L., & Addington, J. (2014). Metacognitive functioning in individuals at clinical high risk for psychosis. Behavioural and Cognitive Psychotherapy, 42, 526-534. doi:10.1017/S1352465813000167

Participants (153 CHR individuals; 68 help seeking controls, HSC) were part of the large multi-site PREDICT study, which sought to determine predictors of conversion to psychosis. They were tested at baseline and 6 months using the MetaCognitions Questionnaire (MCQ) that has five sub-scales assessing different domains of metacognition....read more
Published

Keywords: schizophrenia, social cognition, assessment, narrative
The use of narrative sampling in the assessment of social cognition: The Narrative of Emotions Task (NET)

*Buck, B., Ludwig, K., & Penn, D. L. (2014). The use of narrative sampling in the assessment of social cognition: The Narrative of Emotions Task (NET). Psychiatry Research, 217, 233-239. doi:10.1016/j.psychres.2014.03.014

The present study evaluates the psychometric properties of a measure called the Narrative of Emotions Task (NET). The NET was used to assess the performance of participants with a diagnosis of schizophrenia or schizoaffective disorder and nonclinical controls....read more
Published

Keywords: severe mental illness, clinical training,
graduate training, stigma
Self-reported confidence and comfort treating severe mental illnesses among pre-doctoral graduate students in clinical psychology

*Buck, B., Romeo, K. H., Olbert, C. M., & Penn, D. L. (2014). Self-reported confidence and comfort treating severe mental illnesses among pre-doctoral graduate students in clinical psychology. Journal of Mental Health, 23, 297-302. doi:10.3109/09638237.2014.924048

The aim of this study was to examine whether students express discomfort working with this population and whether they are satisfied with their level of training in SMI. One-hundred sixty-nine students currently enrolled in doctoral programs in clinical psychology in the United States and Canada were surveyed for their comfort treating and satisfaction with training related to a number of disorders....read more
Published

Keywords: cardiometabolic risk, first-episode psychosis, schizophrenia, RAISE-ETP
Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: Baseline results from the RAISE-ETP study

Correll, C. U., Robinson, D. G., Schooler, N. R., Brunette, M. F., Mueser, K. T., Rosenheck, R. A., Marcy, P., Addington, J., Estroff, S. E., Robinson, J., Penn, D. L., Azrin, S., Goldstein, A., Severe, J., Heinssen, R., & Kane, J. M. (2014). Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: Baseline results from the RAISE-ETP study. Journal of the American Medical Association, 71, 1360-1363. doi:10.1001/jamapsychiatry.2014.1314

This study assessed cardiometabolic risk in first-episode schizophrenia spectrum disorders (FES) and its relationship to illness duration, antipsychotic treatment duration and type, sex, and race/ethnicity. Baseline results of the Recovery After an Initial Schizophrenia Episode (RAISE) study, collected between July 22, 2010, and July 5, 2012, from 34 community mental health facilities without major research, teaching, or clinical FES programs....read more

Web of Science highly cited paper as of May 2021
Published

Keywords: oxytocin, schizophrenia, social cognition, social functioning
A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia

*Gibson, C. M., Penn, D. L., Smedley, K. L., Leserman, J., Elliott, T., & Pedersen, C. A. (2014). A pilot six-week randomized controlled trial of oxytocin on social cognition and social skills in schizophrenia. Schizophrenia Research, 156, 261-265. doi:10.1016/j.schres.2014.04.009

The current study explored whether oxytocin can improve social cognition and social skills in individuals with schizophrenia using a six-week, double-blind design. Fourteen participants with schizophrenia were randomized to receive either intranasal oxytocin or a placebo solution and completed a battery of social cognitive, social skills and clinical psychiatric symptom measures....read more
Published

Keywords: alliance, group therapy, hallucinations, schizophrenia
An investigation of the relationship between therapist characteristics and alliance in group therapy for individuals with treatment-resistant auditory hallucinations

*Harper-Romeo, K., Meyer, P. S., Johnson, J., & Penn, D. L. (2014). An investigation of the relationship between therapist characteristics and alliance in group therapy for individuals with treatment-resistant auditory hallucinations. Journal of Mental Health, 23, 166-170. doi:10.3109/09638237.2013.869568

This study investigates the relationship between therapist characteristics and group alliance in 65 individuals with schizophrenia receiving outpatient group therapy for treatment resistant auditory hallucinations. Raters coded 120 sessions of cognitive behavioral therapy or supportive therapy for therapist warmth and friendliness, therapist exploration and negative therapist attitude....read more
Published

Keywords: schizophrenia, measurement, emotion processing, social perception, theory of mind, attributions, SCOPE
The social cognition psychometric evaluation study: Results of the expert survey and RAND panel

*Pinkham, A. E., Penn, D. L., Green, M. F., Buck, B., Healey, K., & Harvey, P. D. (2014). The social cognition psychometric evaluation study: Results of the expert survey and RAND panel. Schizophrenia Bulletin, 40, 813-823. doi:10.1093/schbul/sbt081

Experts in social cognition were invited to nominate key domains of social cognition and the best measures of those domains. Nominations for measures were reduced according to set criteria, and all available psychometric information about these measures was summarized and provided to RAND panelists. Panelists rated the quality of each measure on multiple criteria, and diverging ratings were discussed at the in-person meeting to obtain consensus....read more

Web of Science highly cited paper as of May 2021
Published

Keywords: schizophrenia, social cognition, Social Cognition and Interaction Training (SCIT)
A randomized, controlled trial of Social Cognition and Interaction Training (SCIT) for outpatients with schizophrenia spectrum disorders

*Roberts, D. L., Combs, D. R., Willoughby, M., Mintz, J., Marks-Gibson, C., Rupp, B., & Penn, D. L. (2014). A randomized, controlled trial of Social Cognition and Interaction Training (SCIT) for outpatients with schizophrenia spectrum disorders. British Journal of Clinical Psychology, 53, 281-298. doi:10.1111/bjc.12044

The current article reports on a controlled trial of 66 adults with schizophrenia randomized to receive either SCIT (n = 33), delivered in weekly group sessions, or treatment as usual (n = 33) for 6 months. Participants completed assessments of social cognition, social functioning, neurocognition and symptoms at baseline, post-treatment, and 3-month follow-up....read more
Published

Keywords: schizophrenia, theory of mind, facial affect recognition, working memory, attention
Exploratory analysis of social cognition and neurocognition in individuals at clinical high risk for psychosis

Yong, E., Barbato, M., Penn, D. L., Keefe, R. S. E., Woods, S. W., Perkins, D. O., & Addington, J. (2014). Exploratory analysis of social cognition and neurocognition in individuals at clinical high risk for psychosis. Psychiatry Research, 218, 39-43. doi:10.1016/j.psychres.2014.04.003

The aim of this study was to extend the current knowledge of the relationship between social cognition and neurocognition in individuals at clinical high risk (CHR) of developing psychosis by examining, in a large sample, the associations between a wide range of neurocognitive tasks and social cognition. Participants included 136 young people at CHR....read more

2013

Published

Keywords: schizophrenia, clinical high-risk, neurocognition, social cognition, functional outcome, mediation
Social cognition as a mediator between neurocognition and functional outcome in individuals at clinical high risk for psychosis

Barbato, M., Liu, L., Penn, D. L., Keefe, R. S. E., Perkins, D. O., Woods, S. W., & Addington, J. (2013). Social cognition as a mediator between neurocognition and functional outcome in individuals at clinical high risk for psychosis. Schizophrenia Research, 150, 542-546. doi:10.1016/j.schres.2012.06.012

In schizophrenia, neurocognition, social cognition and functional outcome are all inter-related, with social cognition mediating the impact that impaired neurocognition has on functional outcome. Less clear is the nature of the relationship between neurocognition, social cognition and functional outcome in individuals at clinical high risk (CHR) for psychosis. 137 CHR participants...read more
Published

Keywords: emotion perception, nonclinical paranoia, social cognition, social functioning
Social cognition and social functioning in nonclinical paranoia

*Combs, D. R., Finn, J. A., Wohlfahrt, W., Penn, D. L., & Basso, M. R. (2013). Social cognition and social functioning in nonclinical paranoia. Cognitive Neuropsychiatry, 18, 531-548. doi:10.1080/13546805.2013.766595

Persons with nonclinical paranoia show many of the same biases as those with clinical paranoia, suggesting that paranoia exists on a continuum. However, little is known about the various social cognitive processes found in paranoia and how these relate to social functioning and social behaviours in general. This study will examine performance on emotion perception and attributional style measures and their relationship to social functioning, social problem solving, and social skill...read more
Published

Keywords: cognitive–behavioral therapy, CBTPsychosis, internet-based psychotherapy, schizophrenia, auditory hallucinations
Web-based cognitive–behavioral therapy for auditory hallucinations in persons with psychosis: A pilot study

Gottlieb, J. D., Harper-Romeo, K., Penn, D. L., Mueser, K. T., & Chiko, B. P. (2013). Web-based cognitive–behavioral therapy for auditory hallucinations in persons with psychosis: A pilot study. Schizophrenia Research, 145, 82-87. doi:10.1016/j.schres.2013.01.002

CBT for Psychosis (CBTp) is an empirically-supported intervention for schizophrenia, but few people have access to it in the U.S. “Coping with Voices” is an interactive, computerized self-directed web-based CBTp program developed to increase access to CBTp with the objective of reducing the severity, distress, and functional impairment caused by auditory hallucinations...read more
Published

Keywords: social cognition, social neuroscience, schizophrenia, clinical trials
Going From Social Neuroscience to Schizophrenia Clinical Trials

Green, M. F. & Penn, D. L. (2013). Going from social neuroscience to schizophrenia clinical trials. Schizophrenia Bulletin, 39, 1189-1191. doi:10.1093/schbul/sbt128

The goals of the project Social Cognition and Functioning in Schizophrenia (SCAF) were to (1) identify the domains to target from social neuroscience for translation to clinical schizophrenia research, (2) identify the paradigms that represent these domains for which the neural substrates are well documented, (3) adapt these paradigms for use in schizophrenia clinical trials, (4) assess the psychometric properties of these measures, and (5) assess the external validity of these measures...read more
Published

Keywords: clinical high risk, schizophrenia, social cognition, theory of mind, social judgments, longitudinal study
Theory of mind and social judgments in people at clinical high risk of psychosis

*Healey, K., Penn, D. L., Perkins, D. O., Woods, S., & Addington, J. (2013). Theory of mind and social judgments in people at clinical high risk of psychosis. Schizophrenia Research, 150, 498-504. doi:10.1016/j.schres.2013.08.038

Social cognitive deficits are consistently reported in psychotic populations. Few studies have longitudinally investigated social cognition in clinical high-risk (CHR) populations. 147 CHR individuals and 85 help seeking controls (HSC) were assessed for up to 2 years; 28 participants developed psychosis across both groups...read more
Published

Keywords: social neuroscience, schizophrenia, psychometrics
Adapting social neuroscience measures for schizophrenia clinical trials, Part 2: Trolling the depths of psychometric properties.

Kern, R. S., Penn, D. L., Lee, J., Horan, W. P., Reise, S. P., Ochsner, K. N., Marder, S. R., & Green, M. F. (2013). Adapting Social Neuroscience Measures for Schizophrenia Clinical Trials, Part 2: Trolling the Depths of Psychometric Properties. Schizophrenia Bulletin, 39, 1201-1210. doi:10.1093/schbul/sbt127

The psychometric properties of 4 paradigms adapted from the social neuroscience literature were evaluated to determine their suitability for use in clinical trials of schizophrenia. This 2-site study (University of California, Los Angeles and University of North Carolina) included 173 clinically stable schizophrenia outpatients and 88 healthy controls...read more
Published

Keywords: social cognition, bipolar disorder, psychotherapy, theory of mind, cognitive bias
Social cognition and interaction training (SCIT) for outpatients with bipolar disorder

Lahera, G., Benito, A., Montes, J. M., Fernandez-Liria, A., Olbert, C. M., & Penn, D. L. (2013). Social cognition and interaction training (SCIT) for outpatients with bipolar disorder. Journal of Affective Disorders, 146, 132-136. doi:10.1016/j.jad.2012.06.032

Patients with bipolar disorder show social cognition deficits during both symptomatic and euthymic phases of the illness, partially independent of other cognitive dysfunctions and current mood. Previous studies in schizophrenia have revealed that social cognition is a modifiable domain. Social cognition and interaction training (SCIT) is an 18-week, manual-based, group treatment designed to improve social functioning by way of social cognition...read more
Published

Keywords: schizophrenia, contextual modulation, facial affect processing, social cognition
An Intact Social Cognitive Process in Schizophrenia: Situational Context Effects on Perception of Facial Affect

Lee, J., Kern, R. S., Phillippe-Olivier, H., Horan, W. P., Kee, K., Ochsner, K., Penn, D. L., & Green, M. F. (2013). An intact social cognitive process in schizophrenia: Situational context effects on perception of facial affect. Schizophrenia Bulletin, 39, 640-647. doi:10.1093/schbul/sbs063

Impaired facial affect recognition is the most consistent social cognitive finding in schizophrenia. Although social situations provide powerful constraints on our perception, little is known about how situational context modulates facial affect recognition in schizophrenia. Study 1 was a single-site study with 34 schizophrenia patients and 22 healthy controls. Study 2 was a 2-site study with 68 schizophrenia patients and 28 controls...read more
Published

Keywords: psychosis, comorbid, prodrome, cognitive behavior therapy, randomized controlled trial
Psychosocial treatments for schizophrenia

Mueser, K. T., Deavers, F., Penn, D. L., & Cassisi, J. C. (2013). Psychosocial treatments for schizophrenia. Annual Review of Clinical Psychology, 9, 465-497. doi:10.1146/annurev-clinpsy-050212-185620

The current state of the literature regarding psychosocial treatments for schizophrenia is reviewed within the frameworks of the recovery model of mental health and the expanded stress-vulnerability model. Interventions targeting specific domains of functioning, age groups, stages of illness, and human service system gaps are classified as evidence-based practices or promising practices according to the extent to which their efficacy is currently supported by meta-analyses and individual randomized controlled trials (RCTs)...read more
Published

Keywords: schizophrenia, social cognition, social
neuroscience, functional outcome
Adapting social neuroscience measures for schizophrenia clinical trials, Part 3: Fathoming external validity

*Olbert, C. M., Penn, D. L., Kern, R. S., Lee, J., Horan, W. P., Reise, S. P., Ochsner, K. N., Marder, S. R., & Green, M. F. (2013). Adapting social neuroscience measures for schizophrenia clinical trials, Part 3: Fathoming external validity. Schizophrenia Bulletin, 39, 1211-1218. doi:10.1093/schbul/sbt130

It is unknown whether measures adapted from social neuroscience linked to specific neural systems will demonstrate relationships to external variables. Four paradigms adapted from social neuroscience were administered to 173 clinically stable outpatients with schizophrenia to determine their relationships to functionally meaningful variables and to investigate their incremental validity beyond standard measures of social and nonsocial cognition...read more
Published

Keywords: schizophrenia, meta-analysis, social cognition, highly cited
Deficits in domains of social cognition in schizophrenia: A meta-analysis of the empirical evidence

Savla, G. N., Vella, L., Armstrong, C. C., Leshen, M. A., Penn, D. L., & Twamley, E. W. (2013). Deficits in domains of social cognition in schizophrenia: A meta-analysis of the empirical evidence. Schizophrenia Bulletin, 39, 979-992. doi:10.1093/schbul/sbs080

Social cognition is strongly associated with functional outcome in schizophrenia, making it an important target for treatment. Our goal was to examine the average magnitude of differences between schizophrenia patients (SCs) and normal comparison (NCs) patients across multiple domains of social cognition recognized by the recent NIMH consensus statement: theory of mind (ToM), social perception, social knowledge, attributional bias, emotion perception, and emotion processing...read more

Web of Science highly cited paper as of May 2021

2012

Published

Keywords: psychosis prodrome, social cognition, affect recognition, facial affect, affective prosody
Affect recognition in people at clinical high risk of psychosis

Addington, J., Piskulic, D., Perkins, D., Woods, S., Liu, L., & Penn, D. L. (2012). Affect recognition in people at clinical high risk of psychosis. Schizophrenia Research, 140, 87-92. doi:10.1016/j.schres.2012.06.012

Individuals with schizophrenia demonstrate stable deficits in affect recognition. Similar deficits in affect recognition have been observed in those who are at clinical high risk (CHR) of developing psychosis. The current project aimed to longitudinally examine affect processing in CHR individuals, to determine if affect processing predicted later conversion to psychosis...read more
Published

Keywords: positive psychology, schizophrenia treatment, recovery, social functioning
Positive living: A pilot study of group positive psychotherapy for people with schizophrenia

*Meyer, P.S., Johnson, D. P., Parks, A., Iwanski, C., & Penn, D. L. (2012). Positive living: A pilot study of group positive
psychotherapy for people with schizophrenia Journal of Positive Psychology, 7, 239-248. doi:10.1080/17439760.2012.677467

Positive psychology interventions target positive emotions in order to increase happiness, engagement in life, and well being while also ameliorating the impact of symptoms on a person's life. We examined an adapted version of group positive psychotherapy for people with schizophrenia (Positive Living (PL)) in a pilot study. Sixteen participants...read more
Published

Keywords: cynicism, discriminant correspondence analysis, paranoia, social cognition, autism, schizophrenia, autism spectrum disorder
Qualitatively distinct factors contribute to elevated rates of paranoia in autism and schizophrenia

*Pinkham, A. E., Sasson, N. J., Beaton, D., Abdi, H., Kohler, C. G., & Penn, D. L. (2012). Qualitatively distinct factors contribute to elevated rates of paranoia in autism and schizophrenia. Journal of Abnormal Psychology, 121, 767-777. doi:10.1037/a0028510

A converging body of clinical and empirical reports indicates that autism features elevated rates of paranoia comparable to those of individuals with paranoid schizophrenia. However, the distinct developmental courses and symptom manifestations of these two disorders suggest that the nature of paranoid ideation may differ between them in important and meaningful ways...read more
Published

Keywords: treatment center, multi-element treatment center, psychosis treatment, schizophrenia spectrum disorders, evaluation
Evaluation of a multi-element treatment center for early psychosis in the United States

*Uzenoff, S. R., Penn, D. L., Graham, K. A., Saade, S., Smith, B. B., & Perkins, D. O. (2012). Evaluation of a multi-element treatment center for early psychosis in the United States. Social Psychiatry and Psychiatric Epidemiology, 47, 1607-1615. doi:10.1007/s00127-011-0467-4

A growing body of research has demonstrated the potential for comprehensive, phase-specific care to improve clinical and functional outcomes in early psychosis. However, there have been no evaluations of such treatment models in the United States (US). This study is a naturalistic, prospective 1-year follow-up of an early psychosis cohort treated in one of the first US-based multi-element treatment centers...read more

2011

Published

Keywords: attention shaping, emotion perception, social cognition, remediation, outpatients, impaired controls
Attention shaping as a means to improve emotion perception deficits in outpatients with schizophrenia and impaired controls

*Combs, D. R., Chapman, D., Waguspack, J., Basso, M. R., & Penn, D. L. (2011). Attention shaping as a means to improve emotion perception deficits in outpatients with schizophrenia and impaired controls. Schizophrenia Research, 127, 151-156. doi:10.1016/j.schres.2010.05.011

Deficits in emotion perception are common in people with schizophrenia and current research has focused on improving these deficits. In our previous research, we demonstrated that directing attention to salient facial features via attention shaping can improve these deficits among...read more
Published

Keywords: social cognition, neurocognition, social functioning, schizophrenia
An examination of social cognition, neurocognition, and symptoms as predictors of social functioning in schizophrenia

*Combs, D. R., Waguspack, J., Chapman, D., Basso, M. R., & Penn, D. L. (2011). An examination of social cognition, neurocognition, and symptoms as predictors of social functioning in schizophrenia. Schizophrenia Research, 128, 177-178. doi:10.1016/j.schres.2010.11.019

Social cognition has emerged as an important construct in schizophrenia. Previous research has shown that social cognition functions as a direct predictor, mediator, or moderator of social functioning (as reviewed in Wölwer et al., 2010). In particular, the ability to recognize different emotional...read more
Published

Keywords: schizophrenia, psychosis, functional outcome, community functioning, quality of life, neurocognition, social cognition
The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: A meta-analysis

Fett, A. K., Viechtbauer, W., Gracia-Dominguez, M., Penn, D. L., van Os, J., & Krabbendam, L. (2011). The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: A meta-analysis. Neuroscience and Biobehavioral Reviews, 35, 573-588. doi:10.1016/j.neubiorev.2010.07.001

The current systematic review and meta-analysis provides an extended and comprehensive overview of the associations between neurocognitive and social cognitive functioning and different types of functional outcome. Literature searches were conducted in MEDLINE and PsycINFO and...read more

Web of science highly cited paper as of December 2020
Published

Keywords: positive psychology, recovery, psychosis
A pilot study of loving kindness meditation for the negative symptoms of schizophrenia

*Johnson, D. P., Penn, D. L., Fredrickson, B. L., Kring, A. M., Meyer, P. S., Catalino, L., & Brantley, M. (2011). A pilot study of loving kindness meditation for the negative symptoms of schizophrenia. Schizophrenia Research, 129, 137-140. doi:10.1016/j.schres.2011.02.015

This pilot study examined loving-kindness meditation (LKM) with 18 participants with schizophrenia-spectrum disorders and significant negative symptoms. Findings indicate that the intervention was feasible and associated with decreased negative symptoms and increased positive emotions...read more
Published

Keywords: schizophrenia, vulnerability, social skill, Theory of Mind
Social skill and social cognition in adolescents at genetic risk for psychosis

*Gibson, C. M., Penn, D. L., Prinstein, M. J., Perkins, D. O., & Belger, A. (2011). Social skill and social cognition in adolescents at genetic risk for psychosis. Schizophrenia Research, 122, 179-184. doi:10.1016/j.schres.2010.04.018

Adolescents at genetic high risk (GHR) for schizophrenia have shown social skill impairments and there is some evidence to suggest they have Theory of Mind (ToM) deficits; however no research has used a standardized, performance-based behavioral measure to assess social functioning...read more
Published

Keywords: schizophrenia, oxytocin, psychosis, social cognition, Theory of Mind, social perception
Intranasal oxytocin reduces psychotic symptoms and improves theory of mind and social perception in schizophrenia

Pedersen, C. A., Gibson, C. M., Rau, S. W., Salimi, K., Smedley, K. L., Casey, R. L., Leserman, J., Jarskog, L. F., & Penn, D. L. (2011). Intranasal oxytocin reduces psychotic symptoms and improves theory of mind and social perception in schizophrenia. Schizophrenia Research, 132, 50-53. doi:10.1016/j.schres.2011.07.027

Oxytocin has numerous prosocial and antipsychotic-like effects in animals. Prosocial effects of acute intranasal oxytocin administration have also been reported in human subjects. We conducted a randomized, placebo-controlled trial testing the effects of twice daily intranasal...read more
Published

Keywords: psychosocial treatment, early psychosis, functional recovery
A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis

Penn, D. L., Uzenoff, S. R., Perkins, D. O., Mueser, K. T., Hamer, R., Waldheter, E., Saade, S., & Cook, L. (2011). A pilot investigation of the Graduated Recovery Intervention Program (GRIP) for first episode psychosis. Schizophrenia Research, 125, 247-256. doi:10.1016/j.schres.2010.08.006

The Graduated Recovery Intervention Program (GRIP) is a new individual cognitive–behavioral therapy program designed to facilitate functional recovery in people who have experienced an initial episode of psychosis. The purposes of this study were to evaluate the feasibility and tolerability...read more
Published

Keywords: first-episode psychosis, recovery, schizophrenia, supported education, supported employment
Life and treatment goals of individuals hospitalized for first-episode nonaffective psychosis

Ramsay, C. E., Broussard, B., Goulding, S. M., Cristofaro, S., Hall, D., Kaslow, N. J., Killackey, E., Penn, D. L., & Compton, M. T. (2011). Life and treatment goals of individuals hospitalized for first-episode nonaffective psychosis. Psychiatry Research, 189, 344-348. doi:10.1016/j.psychres.2011.05.039

First-episode psychosis typically emerges during late adolescence or young adulthood, interrupting achievement of crucial educational, occupational, and social milestones. Recovery-oriented approaches to treatment may be particularly applicable to this critical phase of the illness, but...read more
Published

Keywords: autism spectrum disorders, social skills, adolescent
Development of the Contextual Assessment of Social Skills (CASS): A role play measure of social skill for individuals with high-functioning autism

*Ratto, A. B., Turner-Brown, L., Rupp, B. M., Mesibov, G. B., & Penn, D. L. (2011). Development of the Contextual Assessment of Social Skills (CASS): A role play measure of social skill for individuals with high-functioning autism. Journal of Autism and Developmental Disorders, 41, 1277-1286. doi:0.1007/s10803-010-1147-z

This study piloted a role play assessment of conversational skills for adolescents and young adults with high-functioning autism/Asperger syndrome (HFA/AS). Participants completed two semi-structured role plays, in which social context was manipulated by changing the confederate’s level...read more

2010

Published

Keywords: Asperger's syndrome, high-functioning autism, schizophrenia, social cognition
Comparison of social cognitive functioning in schizophrenia and high functioning autism: More convergence than divergence

*Couture, S., Penn, D. L., Losh, M., Adolphs, R., Hurley, R., & Piven, J. (2010). Comparison of social cognitive functioning in schizophrenia and high functioning autism: More convergence than divergence. Psychological Medicine, 40, 569-579. doi:10.1017/S003329170999078X

Background: Individuals with schizophrenia and individuals with high-functioning autism (HFA) seem to share some social, behavioral and biological features. Although marked impairments in social cognition have been documented in both groups, little empirical work has compared the social...read more
Published

Keywords: emotions, broaden-and-build, mindfulness, psychopathology, neuroplasticity
Upward spirals of positive emotions counter downward spirals of negativity. Insights from the broaden-and-build theory and affective neuroscience on the treatment of emotion dysfunctions and deficits in psychopathology

Garland, E. L., Fredrickson, B., Kring, A. M., Johnson, D. P., Meyer, P. S., & Penn, D. L. (2010). Upward spirals of positive emotions counter downward spirals of negativity. Insights from the broaden-and-build theory and affective neuroscience on the treatment of emotion dysfunctions and deficits in psychopathology. Clinical Psychology Review, 30, 849-864. doi:10.1016/j.cpr.2010.03.002

This review integrates Fredrickson's broaden-and-build theory of positive emotions with advances in affective neuroscience regarding plasticity in the neural circuitry of emotions to inform the treatment of emotion deficits within psychopathology. We first present a body...read more

Web of science highly cited paper as of December 2020
Published

Keywords: virtual reality, schizophrenia, simulation, empathy, social distance, technology
The virtual doppelganger: Effects of a virtual reality simulator on perceptions of schizophrenia

Kalyanaraman, S., Penn, D. L., Ivory, J. D., & Judge, A. (2010). The virtual doppelganger: Effects of a virtual reality simulator on perceptions of schizophrenia. The Journal of Nervous and Mental Disease, 198, 437-443. doi:10.1097/NMD.0b013e3181e07d66

Recent scholarship suggests that virtual environments can serve as effective proxies in battling implicit stereotypes. However, existing experimental research has rarely examined the effectiveness of virtual simulations of mental illnesses in inducing empathy to combat stereotypical...read more
Published

Keywords: social cognition, signal detection
Antipsychotic medication and social cue recognition in chronic schizophrenia

*Roberts, D. L., Penn, D. L., Corrigan, P. W., Lipkovitch, I., Kinon, B., & Black, R. A. (2010). Antipsychotic medication and social cue recognition in chronic schizophrenia. Psychiatry Research, 178, 46-50. doi:10.1016/j.psychres.2010.04.006

Social cognition has received increased attention in schizophrenia research because it is associated with functional outcomes. Psychosocial interventions are being developed to enhance social cognition, however less attention has been paid to the association between antipsychotic medication...read more
Published

Keywords: schizophrenia, social cognition, Theory of Mind, emotion perception, attributional bias, transportability
Transportability and feasibility of Social Cognition and Interaction Training (SCIT) in community settings

*Roberts, D. L., Penn, D. L., Labate, D., Margolis, S. A., & Stern, A. (2010). Transportability and feasibility of Social Cognition and Interaction Training (SCIT) in community settings. Behavioral and Cognitive Psychotherapy, 38, 35-47. doi:10.1017/S1352465809990464

Background: Social Cognition and Interaction Training (SCIT) is a manual-based group intervention designed to improve social cognition in schizophrenia. Initial studies conducted by the developers of SCIT suggest that the intervention has promise in ameliorating social cognitive...read more
Published

Keywords: psychology, psychotic disorders, quality of life
Psychological well-being among individuals with first-episode psychosis
*Uzenoff, S. R., Brewer, K. C., Perkins, D. L., Johnson, D. P., Mueser, K. T., & Penn, D. L. (2010). Psychological well-being among individuals with first-episode psychosis. Early Intervention in Psychiatry, 4, 174-181. doi:0.1111/j.1751-7893.2010.00178.x

Aim: Psychological well-being is a subjective component of quality of life (QOL) that has been previously unexplored in individuals recovering from an initial psychotic episode. This study examined predictors of psychological well-being among individuals with first-episode psychosis (FEP)...read more